Abstract:Purpose：To effectively address the disposal issues of gold tailings and alleviate the shortage of sandstone resources, this study investigated the potential of utilizing gold tailings as a partial replacement for natural sand in the production of gold tailings concrete. Method： Through a series of cube compressive strength tests and orthogonal experimental methods, this research conducted a comprehensive analysis of the impacts of four factors: water-binder ratio, gold tailings substitution rate, sand ratio, and fly ash content, on the 28-day compressive strength of gold tailings concrete. The systematic analysis was performed using range and variance analysis methods, which determined the relative importance of each factor in influencing the 28-day compressive strength of the concrete. Furthermore, a multiple regression equation was established for predicting the compressive strength of gold tailings concrete based on the orthogonal experimental data. Conclusion： The results indicated that the water-binder ratio had the most significant effect on the compressive strength, followed by the gold tailings substitution rate, fly ash content, and sand ratio. The regression equation, with an R2 value of 0.872, can predict the compressive strength to a considerable degree. Significance： The research results can provide some reference value for the comprehensive utilization of gold tailings resources.