Abstract:The stream sediment with the proportion of 1:50000 was taken and four Cu, Pb, Zn polymetallic prospecting areas were marked by Geophysical and Geochemical Survey,Non-ferrous Metals and Nuclear Industry Geological Exploration Bureau of Guizhou,in Tuozhi-Guadeng region,2013. Wide-ranging tectonic movements in Himalayan period cut through the lithospheric mantle,the extensive stratify , extensive strike slip, thrusting and extension movement that form the delamination and slippage of lithosphere, which caused partial melting of lithosphere and asthenosphere upwelling, and a serials of metamorphism, superimposition along with clastic rocks and carbonatite formation. finally, formed exhalation-sedimentary deposit primarily of Cu、Pb and Zn, through the study of the deposits in the region, show that the region has the prospecting potential for large-super large polymetallic deposits.