| The water soaking, the ammonia and the CaO are used to neutralize uranium tailings from heap leaching for determining the suitable neutralization. Samples, with determined neutralization, slurry concentrations, cement-tailing ratios and different curing time, are prepared by using the heap leaching tailing cemented backfills, and the uniaxial compressive strengths are measured by using RMT-150B rock mechanics testing machine. Based on the test results, the heap leaching tailings cemented backfills, with the slurry concentration of 80% and cement-tailing ratio of 1︰8, is used to fill the test stope in a uranium mine, and the stress measurements are conducted for the backfills. The results show that the CaO, the consumption of 0.2% of the dry weight of the tailings, is the suitable neutralization. The slurry concentration and cement-tailing ratio are the key factors to influence on the compressive strength of the backfills, meanwhile, the compressive strength of the backfills increase with the increase of the slurry concentration, while decrease with the increase of the cement-tailing ratio. The compressive strength of backfills, with the slurry concentration of 80% and cement-tailing ratio of 1︰8, is larger than 2 MPa at the solidification duration of 7 days, and the collapsbillity is 13 mm. The stress measurements of the determined backfills is lower than its compressive strength, which means that it can be used to effectively control the ground pressure in deep stope mining.